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KEGG enriched themes and their interaction map, illustrating the...
KEGG enriched themes and their interaction map, illustrating the transcriptomic signature of WAT in obese subjects three months after gastric bypass
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GO Biological Process enriched themes and their interaction map,...
GO Biological Process enriched themes and their interaction map, illustrating the transcriptomic signature of WAT in obese subjects three months after gastric bypass
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GO Cellular Component enriched themes and their interaction map,...
GO Cellular Component enriched themes and their interaction map, illustrating the transcriptomic signature of WAT in obese subjects three months after gastric bypass
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Significant correlations between the BMI and the expression profiles of the...
Significant correlations between the BMI and the expression profiles of the genes annotated with themes composing the second GO Biological Process interaction module in obese WAT
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Significant correlations between the BMI and the expression profiles of the...
Significant correlations between the BMI and the expression profiles of the genes annotated with themes composing the first GO Biological Process interaction module in obese WAT
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Co-expression network of ECM related genes showing significant differential...
Co-expression network of ECM related genes showing significant differential expression in obese WAT
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Gene co-expression network underlying the GO Biological Process interaction...
Gene co-expression network underlying the GO Biological Process interaction map in obese WAT
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KEGG enriched themes and their interaction map, illustrating the...
KEGG enriched themes and their interaction map, illustrating the transcriptomic signature of obese WAT
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GO Biological Process enriched themes and their interaction map,...
GO Biological Process enriched themes and their interaction map, illustrating the transcriptomic signature of obese WAT
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GO Cellular Component enriched themes and their interaction map,...
GO Cellular Component enriched themes and their interaction map, illustrating the transcriptomic signature of obese WAT
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Volcano plot of genes differentially expressed between trisomic and control...
Volcano plot of genes differentially expressed between trisomic and control samples
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DSH/NH ratio of gene expression calculated for each chromosome and for all...
DSH/NH ratio of gene expression calculated for each chromosome and for all the chromosomes
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Enriched GO categories for upregulated genes, sorted by p-value
Enriched GO categories for upregulated genes, sorted by p-value
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Enriched GO categories for down-regulated genes, sorted by p-value of the...
Enriched GO categories for down-regulated genes, sorted by p-value of the comparison between observed and expected data
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Average expression ratios (DS samples/controls) calculated from microarray...
Average expression ratios (DS samples/controls) calculated from microarray and RT-PCR data and Pearson correlation coefficient (r) between microarray and RT-PCR data. Hsa21 genes are in bold.
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Characteristics of the samples analyzed in the study
Characteristics of the samples analyzed in the study
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Volcano plots obtained by comparing DS fetuses with and without cardiac...
Volcano plots obtained by comparing DS fetuses with and without cardiac defects
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Expression level of DSCR1 and NFATC3 genes in individual heart samples
Expression level of DSCR1 and NFATC3 genes in individual heart samples
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Genes and gene pathways affected by Hsa21 trisomy
Genes and gene pathways affected by Hsa21 trisomy
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Enriched KEGG pathways for switch-like genes identified in alternate modes...
Enriched KEGG pathways for switch-like genes identified in alternate modes of expression in diabetes. Enriched KEGG pathways are shown for bimodal genes that switch states between healthy tissue and...
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Switch-like genes identified in alternate modes of expression in diabetes....
Switch-like genes identified in alternate modes of expression in diabetes. Quantities of bimodal genes that are in alternate modes between healthy tissue and disease tissue are shown for diabetes type...
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Enriched GO terms for switch-like genes. Terms are organized by cellular...
Enriched GO terms for switch-like genes. Terms are organized by cellular component (CC), biological process (BP), and molecular function (MF). Enrichment scores are the number of observed genes over...
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Enriched KEGG pathways for switch-like genes. Enrichment scores are the...
Enriched KEGG pathways for switch-like genes. Enrichment scores are the number of observed genes over the number of expected genes. P-values were computed using the hypergeometric distribution.
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Mouse gene expression datasets and tissue types composing our diabetes...
Mouse gene expression datasets and tissue types composing our diabetes dataset.
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Mouse gene expression datasets and tissue types composing our healthy dataset.
Mouse gene expression datasets and tissue types composing our healthy dataset.
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Identification of switch-like genes with bimodal gene expression
Identification of switch-like genes with bimodal gene expression
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Bimodal genes highlighted in KEGG focal adhesion diagram
Bimodal genes highlighted in KEGG focal adhesion diagram
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Bimodal genes highlighted in KEGG ECM-receptor interaction diagram
Bimodal genes highlighted in KEGG ECM-receptor interaction diagram
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Tissue selective genes common among nineteen tissue types
Tissue selective genes common among nineteen tissue types
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The average afferent sensitivity at 2 Hz varies in proportion to the square...
The average afferent sensitivity at 2 Hz varies in proportion to the square of the internal radius of the semicircular canals
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There is no difference between the sensitivity and phase lead with respect...
There is no difference between the sensitivity and phase lead with respect to head velocity for juvenile in comparison to adult mice during 2 Hz rotations
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Complement of eLRR proteins by group, localisation and species
Complement of eLRR proteins by group, localisation and species
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eLRR protein predicted architectures (part 2)
eLRR protein predicted architectures (part 2)
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Concentration-dependent inhibition of hippocampal CA1 field EPSPs by...
Concentration-dependent inhibition of hippocampal CA1 field EPSPs by WIN55,212-2. (A) Time course shows a cumulative concentration-response experiment where increasing bath concentrations of...
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Inhibition of GABAergic transmission in a stratum radiatum interneuron by...
Inhibition of GABAergic transmission in a stratum radiatum interneuron by WIN55,212-2. IPSCs were evoked by paired (100 ms) stimuli every 30 s. Under control conditions, the response showed...
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DIC-IR image of a stratum radiatum interneuron in a hippocampal brain slice....
DIC-IR image of a stratum radiatum interneuron in a hippocampal brain slice. The slice was cut at 300 µm, and the depth of the recorded cell was approx 175 µm from the surface of the slice. (A) The...
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ConSurf structural conservation analysis revealed that highly conserved...
ConSurf structural conservation analysis revealed that highly conserved residues in PgdA orthologs and paralogs surround the enzyme’s acetyl-binding groove (Figure 1 )..
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Overall clinical and biological parameters of 55 obese subjects and 15 lean...
Overall clinical and biological parameters of 55 obese subjects and 15 lean controls
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A sketch of the hypothetical map of pathophysiological interactions taking...
A sketch of the hypothetical map of pathophysiological interactions taking place in obese WAT
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Macrophages promote ECM component secretion by pre-adipocytes
Macrophages promote ECM component secretion by pre-adipocytes
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Functional profiles illustrating the transcriptomic signature of human...
Functional profiles illustrating the transcriptomic signature of human pre-adipocytes cultivated with AcMC-conditioned media
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Quantification and characterization of interstitial fibrosis in subcutaneous...
Quantification and characterization of interstitial fibrosis in subcutaneous WAT (scWAT) of morbidly obese subjects
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Presence of macrophages, T lymphocytes and NK cells in the subcutaneous WAT...
Presence of macrophages, T lymphocytes and NK cells in the subcutaneous WAT of morbidly obese subjects
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Major functional groups overrepresented among state-change genes and...
Major functional groups overrepresented among state-change genes and corresponding overrepresented TREs. The groups are presented according to the order of significance identified by DAVID....
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Transcription factor activity identified in silico and in vivo
Transcription factor activity identified in silico and in vivo
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The NFκB canonical signaling pathway from IPA
The NFκB canonical signaling pathway from IPA
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Visualization of changes in gene expression level identified by microarray...
Visualization of changes in gene expression level identified by microarray analysis
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Identification of hypervariable and differentially expressed genes
Identification of hypervariable and differentially expressed genes
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Identification of noise level and microarray adjustment
Identification of noise level and microarray adjustment
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Schematic diagram of steps in microarray analysis
Schematic diagram of steps in microarray analysis
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